Circulatory MIC-1 as a Determinant of Prostate Cancer Racial Disparity
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms involving prostate cancer racial disparity.
Prostate cancer (PCa) is the second leading cause of cancer-related deaths in the United States. The African (AA) descent has greater incidence and mortality rates of PCa as compared to Caucasian (CA) men. While socioeconomic differences across racial groups contribute to disparity in PCa, increasing evidence points that genetic and molecular alterations play important roles in racial dispariti...
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INTRODUCTION Race may be a significant factor that influences prostate cancer (PCa) survival, with the Asian (AsA) race being associated with better outcomes compared to African American (AA) and Non-Hispanic Whites (NHW). This study evaluates race-dependent variation in PCa-specific mortality (PCSM) associated with radiation dose-escalation exemplified by external beam radiotherapy (EBRT) with...
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Genetic mutations and metabolic reprogramming are two key hallmarks of cancer, required for proliferation, invasion, and metastasis of the disease. While genetic mutations, whether inherited or acquired, are critical for the initiation of tumor development, metabolic reprogramming is an effector mechanism imperative for adaptational transition during the progression of cancer. Recent findings i...
متن کاملHigh prevalence of screen detected prostate cancer in West Africans: implications for racial disparity of prostate cancer.
PURPOSE To our knowledge the reasons for the high rates of prostate cancer in black American men are unknown. Genetic and lifestyle factors have been implicated. Better understanding of prostate cancer rates in West African men would help clarify why black American men have such high rates since the groups share genetic ancestry and yet have different lifestyles and screening practices. To esti...
متن کاملcomplexity of the socioeconomic status and its disparity as a determinant of health
the socioeconomic (se) status is considered tobe one of the most important health risk factorsnowadays. a simple search showed that onlyin 2011, more than 1100 articles were cited inpubmed about the relationship of health and sestatus. however, there are many inquiries aboutthis association. the se status is a complex andmultidimensional issue, and there is no goldstandard method to measure it,...
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ژورنال
عنوان ژورنال: Cancers
سال: 2020
ISSN: 2072-6694
DOI: 10.3390/cancers12103033